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This regulatory reality doesn't mean the combinations are dangerous

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During T-cell signaling, it must be reduced in order for the TCR/MHCII/CD4 receptor complex to form: a process that requires CD4 dimerization and domain swapping (Cerutti et al., 2014)

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These changes are not permanent, but they are enough to buy time for cells to acquire the mutations that eventually make them genetically resistant

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